Mourinho’s future at Manchester United remains in doubt after a turbulent start to the season on and off the pitch.
The Red Devils are eighth in the Premier League table having lost three of their first eight games.
Their task does not get any easier as they visit unbeaten Chelsea this Saturday at Stamford Bridge (12.30pm).
Mourinho is said to have fallen out with star midfielder Paul Pogba and there are also murmurings about a breakdown in relations with other key players.
Manchester United did win their last outing, coming from two goals down to beat Newcastle 3-2, but Mourinho remains the favourite with the bookies to be the next Premier League boss to lose his job.
ESPN presenter Ross Dyer asked Moreno what he would do to improve United.
“If there’s one way that you could improve them, what would you do first?” Dyer said.
“Change the system? Change the manager? Change certain players? Is there a player missing that you would bring in?
“What is the first thing that you would try and do?”
And Moreno was unequivocal in his response, claiming getting rid of Mourinho is the answer to the solution.
“I’d change the manager. I think that boat has gone,” the Venezuelan replied.
“That ship has sailed in terms of the communication between the manager and the response from the players.
“There are moments in which you see, and you don’t even have to be inside that locker room to understand, just from watching that there is a disconnect.
“And when that disconnect happens, it is very difficult to get it back.
“You’re not going to change 25 guys, so it becomes time to say ‘alright, what can we do that really gets the attention of everybody in this organisation?’.
“Ed Woodward is not going anywhere, the players are not going anywhere.
“And so it feels as if it would be Jose Mourinho to go.
“How they go about doing that, that’s a different story.”