Frank Lampard will take his giant-killing Derby County side to former club Chelsea in the fourth round of the Carabao Cup.
Derby beat Manchester United on penalties in the third round and their reward is an away trip to Stamford Bridge.
The other eye-catching tie sees West Ham host London rivals Tottenham.
Defending champions Manchester City have a home clash with Fulham.
Last season’s runners-up Arsenal play League One side Blackpool.
There are two other Premier League vs Championship matches – Bournemouth vs Norwich and Middlesbrough vs Crystal Palace.
Leicester will play the winner of Everton vs Southampton, which takes place next week.
The final match drawn was Burton vs Nottingham Forest.
The matches will be played in week commencing October 29.
CARABAO CUP FOURTH ROUND DRAW
Manchester City vs Fulham
Bournemouth vs Norwich
Arsenal vs Blackpool
Leicester vs Everton or Southampton
West Ham vs Tottenham
Middlesbrough vs Crystal Palace
Chelsea vs Derby
Burton vs Nottingham Forest